health

The Monkey and the Cybernetic Prosthesis

I remember hearing about this development toward the end of 2008, but apparently Sky News has now been “given exclusive access to the laboratory at Pittsburgh University in the United States” and is reporting last year’s news today. Video is via CBS News.


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Andrew Schwartz, professor of neurobiology at the University of Pittsburgh’s School of Medicine is leading a team making some startling discoveries in the field of Brain-Computer Interfaces.

In June 2008, the Pitt Chronicle provided an update on his work:

A monkey has successfully fed itself with fluid, well-controlled movements of a human-like robotic arm by using only signals from its brain, researchers from the University of Pittsburgh School of Medicine report in the journal Nature. This significant advance could benefit the development of prosthetics for people with spinal-cord injuries and those with such “locked-in” conditions as amyotrophic lateral sclerosis (Lou Gehrig’s disease).

This is pretty incredible. The ability to capture signals directly from the brain with sufficient fidelity to allow accurate motor control of a prosthesis will have life-changing effects for anyone with physiological conditions interfering with nerve cell communication and gross muscle control.

“Our immediate goal is to make a prosthetic device for people with total paralysis,” said Andrew Schwartz, senior author and professor of neurobiology in Pitt’s School of Medicine. “Ultimately, our goal is to better understand brain complexity.”

Previously, work has focused on using brain-machine interfaces to control cursor movements displayed on a computer screen. Monkeys in the Schwartz lab have been trained to command cursor movements with the power of their thoughts.

“Now we are beginning to understand how the brain works using brain-machine interface technology,” said Schwartz. “The more we understand about the brain, the better we’ll be able to treat a wide range of brain disorders, everything from Parkinson’s disease and paralysis to, eventually, Alzheimer’s disease, and perhaps even mental illness.”

Next stage: Combat Armoured Suits

Don’t Panic! You don’t have Swine Flu…

…and in the unlikely event that you do it probably won’t cause you any lasting harm. Unless you’re already ill, very old or very young, in which case it still probably won’t kill you.

Furthermore seeing as it is July, you probably don’t have seasonal influenza, and in the unlikely event that you do it probably won’t cause you any lasting harm. Unless you’re already ill, very old or very young, in which case it still probably won’t kill you.

Via the Mail on Sunday:

Twenty million people will be vaccinated against swine flu by Christmas, with everyone receiving the jab by the middle of next year.

Experts are drawing up a priority list of patients to be given immunity before the bug becomes more virulent.

Those first in the queue are expected to be the elderly, infants under the age of five, people with asthma and diabetes, and those with compromised immune systems. NHS and social care workers would also get them first.

It would appear the vaccine they are proposing to jab everyone with is the experimental vaccine currently on the fast track to regulatory approval. The words “fast-track” and “vaccine” in the same sentence don’t fill me with confidence; I think I might wait for someone else to get their shot first.

Here are four reasons to worry less.

Reason #1 – You are more likely to die of something else:

Via the Health Protection Agency (NHS):

HPA receives weekly death registrations from the Office for National Statistics. In week 26/09, an estimated 8433 all-cause deaths were registered, which is a slight decrease compared to 8728 in week 25/09. It should be noted that these deaths are due to all causes and cannot be attributed to influenza. The weekly number is in the expected range for this time of year and no excess deaths have been observed.

Reason #2 – There isn’t that much Swine Flu about

Looking at previous years, here’s a graph derived from Routine influenza data from HPA and NHS laboratories, reported to CDSC on a weekly basis. England and Wales 1992-2007:

Influenza specimens detected in England & Wales from 1992-07 (all strains)

These are years where the World Health Organisation wasn’t declaring a pandemic. (Average 1,949 influenza cases detected per year).

Given the whole pandemic announcement, the press coverage and the people ringing up the Doctors (and NHS Direct) for every cough and sniffle, more samples are being tested so it isn’t too surprising to see a big jump this year. Total UK confirmed (swine) influenza cases are currently 9,718. But:

The overall daily GP ILI consultation rate […] was 9.8 per 100,000 which is equivalent to estimated weekly rates expected when ‘normal seasonal influenza’ is circulating during the winter months.

The total number of influenza detections (community and hospital) characterised by RVU by week 08-09

An interesting comment from medical call centre NHS Direct:

NHS Direct has an existing algorithm for ‘cold/flu’ calls, [and] in response to the current situation, a new algorithm to handle ‘swine flu’ calls was introduced. When both indices are added together, they show that the ‘estimated total’ proportion of cold/flu calls to NHS Direct peaked and decreased very quickly soon after the outbreak was declared in late April. The estimated total proportion of cold/flu calls has increased rapidly again since June.

Unsurprisingly lots of newspaper stories produces lots of calls to NHS Direct and visits to the GP. From a Welsh report:

During week 27, the percentage of total calls to NHS Direct Wales which were influenza related increased to 20.6% from 18.9% in week 26. […] Flu related calls are the sum of calls recorded as 'cold/flu', 'cough', 'headache', 'fever' and 'sore throat'.

Remember that if you hear people talking about huge numbers of calls to NHS Direct. Anything involving a cough, headache, fever or sore throat gets marked down as a flu-related call.

Reason #3 – Swine Flu seems to respond to existing anti-viral drugs:

Again, from the HPA:

Seventeen of the Influenza A (H1N1v) isolates have been fully tested for susceptibility at Respiratory Virus Unit, Centre for Infections, Colindale (RVU); all 17 were found to be sensitive to oseltamivir and zanamivir and resistant to amantadine. One hundred and ninety-nine positive specimens have been analysed for the marker commonly associated with resistance to oseltamivir in seasonal influenza (H274Y), all were found not to carry this marker

(Although if you’re not very old, very young or otherwise ill then taking an anti-viral drug seems a bit excessive)

You probably know oseltamivir under its non-generic brand name Tamiflu.

Reason #4 – Politicians always talk up a crisis that isn’t their fault

Via Reuters:

Britain's Health Minister Andy Burnham said last week the government was projecting more than 100,000 new cases a day of the flu by the end of August.

There would need to be a massive rise in infection rates to get to that sort of figure. According to the World Health Organisation, there aren’t even 100.000 cases worldwide yet. (as of 6th July: 94,512 cases, 429 deaths)

Here’s a graph from the HPA’s Weekly pandemic flu update (9 July 2009):

Satellite

The UK has had about 10,000 cases in the last three months. Getting up to 100,000 new cases every day in the next six weeks seems improbable, even if people do pick it up on their summer holidays.

Certainly, rates will go up. Here’s a week-by-week count of Influenza specimen detection in UK laboratories in 2003-2007.

Influenza specimens detected in England & Wales from 2003-07 (by week)

Notice the peak around the New Year, every year. The non-swine flu variants are called “seasonal flu” for a reason.

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